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SILVER BULLET THERAPEUTICS, INC. , located in San Jose, CA, has developed and patented antimicrobial implants and medical devices to address surgical-site and hospital-acquired infections. The company's first product, the OrthoFuzIon Cannulated Bone Screw, utilizes an advanced silver ion technology that allows for a faster, natural ionization of the silver and creating an antimicrobial zone around the screw to prevent microbial colonization of internal and external surfaces of the screw. OrthoFuzIon is a Trademark of Silver Bullet Therapeutics, Inc. and is approved for sale in Europe and not yet in the United States.